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Enclomiphene (Oral SERM)
compoundedenclomiphene citrate — Not FDA-approved. Available off-label through compounding pharmacies with a prescription. Enclomiphene is an investigational drug whose development was discontinued in 2021.
$99–$199/mo
/month
Dosing
Typically 6.25–25mg taken orally once daily or every other day, with the dose individualized based on lab results and clinical response
Type
Compounded
Key Fact
Enclomiphene is a SERM that may stimulate the body's own testosterone production by blocking estrogen feedback in the hypothalamus, rather than introducing external testosterone. It is not FDA-approved and is only available through compounding pharmacies.
Price
$99–$199/mo
Enclomiphene citrate is a selective estrogen receptor modulator (SERM) that has gained significant attention as a potential alternative to traditional TRT for men with low testosterone. Unlike exogenous testosterone, which replaces the body's natural production, enclomiphene works by blocking estrogen receptors in the hypothalamus, which may signal the body to increase its own testosterone output. This mechanism means that enclomiphene may help preserve fertility — a key concern for many men considering testosterone therapy. It is important to note that enclomiphene is not FDA-approved; its formal development was discontinued in 2021, and it is currently available only through compounding pharmacies with a prescription.
Where to Get Enclomiphene (Oral SERM)
Compare providers offering enclomiphene (oral serm) — ranked by our editorial team
Hims
Enclomiphene is Hims' primary low-testosterone offering. Pricing varies by plan length — $99/mo on 10-month plan, $199/mo on 3-month plan.
$99–$199/mo
/month
TRT Nation
Enclomiphene available alongside testosterone or as a standalone option. Pricing discussed during consultation.
Available as ancillary
/month
Peter MD
Enclomiphene available as a treatment option within Peter MD's all-inclusive TRT plans.
Included in plans from $89/mo
/month
Marek Health
Enclomiphene available as part of individualized protocols. Pricing depends on consultation and medication costs.
Pay-as-you-go
/month
How Enclomiphene (Oral SERM) Works
Enclomiphene is the trans-isomer of clomiphene citrate and acts as a selective estrogen receptor antagonist. In the male body, estrogen normally provides negative feedback to the hypothalamus, signaling it to reduce the production of gonadotropins (LH and FSH) — the hormones that tell the testes to produce testosterone and sperm. By blocking estrogen receptors in the hypothalamus, enclomiphene may remove this negative feedback loop, potentially leading to increased LH and FSH secretion and, in turn, higher natural testosterone production. Because the testes remain active and stimulated, sperm production may be maintained, unlike with exogenous testosterone which typically suppresses it.
Side Effects
Common
- • Headache
- • Nausea
- • Abdominal discomfort
- • Mood changes
- • Hot flashes
- • Fatigue
Serious (Rare)
- • Blood clots (rare, but reported with SERM-class medications)
- • Visual disturbances (reported with related compound clomiphene)
- • Cardiac events (rare, especially in those with pre-existing conditions)
- • Liver enzyme changes
- • The long-term safety profile of enclomiphene has not been extensively studied
Who Is Eligible
Enclomiphene may be considered for men with secondary hypogonadism (where the issue originates in the hypothalamus or pituitary rather than the testes) who have low testosterone levels and want to support natural production. It may be particularly relevant for men who wish to preserve fertility. Enclomiphene is generally not appropriate for men with primary testicular failure, as the testes must be capable of responding to increased gonadotropin signaling. A licensed provider will evaluate your lab results and health history to determine if enclomiphene is a suitable option. Compounded medications are not FDA-approved.