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Sermorelin
compoundedSermorelin acetate — Sermorelin was previously FDA-approved as Geref for diagnostic use, but the branded product has been discontinued. Current sermorelin available through compounding pharmacies is compounded and not FDA-approved for therapeutic use.
$99 - $250/mo
/month
Dosing
Typical protocols involve subcutaneous injection of 200-300mcg administered before bedtime. Some protocols use 5 days on, 2 days off cycling. Dosage is individualized by the prescribing provider based on health goals and lab results.
Type
Compounded
Key Fact
Sermorelin is one of the most conservative and longest-prescribed growth hormone peptides. It stimulates natural GH production rather than introducing exogenous growth hormone directly.
Price
$99 - $250/mo
Sermorelin is a growth hormone-releasing hormone (GHRH) analog that stimulates the pituitary gland to produce and release growth hormone naturally. It was originally FDA-approved as a diagnostic agent (Geref), though the branded product has been discontinued. Today, sermorelin is available through compounding pharmacies as a compounded medication — not FDA-approved for therapeutic use. It is one of the most widely prescribed peptides in the longevity and anti-aging space, valued for its relatively conservative mechanism of stimulating the body's own GH production rather than introducing exogenous growth hormone. Sermorelin is typically administered via subcutaneous self-injection before bedtime to align with the body's natural growth hormone release patterns.
Where to Get Sermorelin
Compare providers offering sermorelin — ranked by our editorial team
AgelessRx
All-inclusive pricing covers consultation, prescription, and shipping. Compounded, not FDA-approved.
$149 - $250/mo
/month
Defy Medical
Individualized protocol with required lab work. Consultation fees ($250-$350 initial) are separate. Compounded, not FDA-approved.
$150 - $250/mo + consultation
/month
Viking Alternative Medicine
Often combined with HRT protocols. Pricing depends on full treatment plan. Compounded, not FDA-approved.
$150 - $300/mo
/month
Push Health
Consultation only — medication costs separate. Provider experience with sermorelin may vary.
~$40/visit + medication
/month
How Sermorelin Works
Sermorelin mimics the action of endogenous growth hormone-releasing hormone (GHRH) by binding to GHRH receptors on the pituitary gland. This stimulation may prompt the pituitary to release growth hormone in a pulsatile pattern similar to the body's natural rhythm. The resulting increase in GH levels may support protein synthesis, fat metabolism, sleep quality, and tissue repair. Because sermorelin works through the body's own regulatory mechanisms, the risk of producing supraphysiologic GH levels is considered lower compared to direct growth hormone injection. The peptide has a relatively short half-life, which is why it is typically dosed nightly.
Side Effects
Common
- • Injection site reactions (redness, swelling, discomfort)
- • Headache
- • Flushing or warmth
- • Dizziness
- • Temporary changes in sleep patterns
Serious (Rare)
- • Allergic reaction — seek medical attention for difficulty breathing, swelling, or severe rash
- • Joint pain or swelling if GH levels become elevated
- • Should not be used by individuals with active cancer — growth hormone stimulation may promote tumor growth
- • Interactions with other medications — disclose full medication list to provider
Who Is Eligible
Sermorelin is generally prescribed to adults with declining growth hormone levels who are interested in supporting recovery, body composition, sleep quality, or general vitality. It is typically not appropriate for individuals with active cancer, pituitary disorders, or certain endocrine conditions. Blood work — including IGF-1 levels — is commonly recommended before starting. This is a compounded medication and is not FDA-approved for therapeutic use.